Description
SDF2, also known as stromal cell-derived factor 2, is believed to be a secretory protein. The amino acid sequence deduced from the murine clone and the human homolog are conserved more than 92%, and the aa sequence of SDF2 shows similarity to those of yeast dolichyl phosphate-D-mannose, protein mannosyltransferases. Its expression is ubiquitous and the gene appears to be relatively conserved among mammals. Also, this protein is involved to stromal derived factors with SDF-1, SDF-4 and SDF-5. These are a loosely defined group of molecules that are generated by stromal cells. SDF group have prognostic value and warrant further investigation in their biological functions and clinical value. Recombinant human SDF2, fused to His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques